韩漫韩漫漫画免费免阅币_韩漫韩漫漫画地址免阅币

Banner
Banner

发布时间:2024-05-05 13:50:11 | 浏览次数：

<img width="400" height="252" alt="" src="data:image/png;base64,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" />  新药研发和试验是一个漫长且耗资巨大的过程。为了制造出前景无限的化合物或者分子，科学家需要进行海量研究。此后，他们还要在动物身上进行试验，如果安全有效则会在人体上进行临床试验。在这个过程中，科学家需要观察药物的安全性和疗效，以及合适的用药剂量。   过去很长一段时间内，科学家一直努力试图简化或者加速这个流程。为此，他们在小型芯片上模拟出人体器官（人工排列人体活细胞，使其模拟完整器官的功能和结构）。这就是所谓的“芯片仿真人体器官系统”（organ-on-a-chip systems）。在未来的某一天，这个系统也许会代替动物试验，同时减少人体试验所需要的步骤和时间。《Nature News》杂志的报道称，这种充满未来主义风格的愿景正在慢慢变成现实。   这是一个“真实”的肺脏，但它不是真的   计算机的微芯片由硅树脂材料打造而成，而芯片仿真人体器官也建造于这样的材料之上：科学向经过专门蚀刻打造的模具中浇筑液态硅胶，模具上有很多槽道，因此硅树脂芯片上也就多了很多槽道。在这些槽道里，科学家安置培育了很多人体细胞。这些细胞从槽道的底部生长，而培养液则会在槽道中流动以便为细胞输送营养。于是，科学家就可以在培养液中加入等待测试的新药或者其他物质，观察其与细胞结合之后的情况。   一般而言，最基础的芯片仿真人体器官仅培育一种类型的细胞。为了模拟不同器官一起工作的状态，科学家需要为基础版本芯片仿真人体器官增加新的功能和特性。比如哈佛大学维斯生物工程研究所（Wyss Institute for Biologically Inspired Engineering）研发的芯片仿真肺部器官复杂度更高，可以模拟具有呼吸功能的肺部。在他们的实验中，工作人员用薄膜隔开了硅树脂芯片上的槽道，使其构成了两个隔室。接着，他们在每个隔室中放入了两种不同类型的肺部细胞：一种可以与薄膜顶部空气完成气体交换，一种可以与隔室底部血液完成气体交换。   为了让这个芯片仿真肺部器官具备呼吸功能，科学家不断向隔室顶部输送空气，同时在隔室底部用液体模仿人体的血液流动。这样一来，他们就可以观察空气中哪种分子可以进入肺部和血液中。这个过程模拟的其实就是人体从空气中获取氧气，然后将氧气储存于血液中并输送给全身细胞。   在另一个实验中，哈佛大学的科学家还展示了一种抗癌症药物对人体的侵害——这种药物会导致液体从薄膜的血液一侧流向空气一侧。在人体中，这种药物会使患者肺部充满液体，从而导致呼吸困难。   生物技术公司和制药公司之间的合作为我们带来了芯片仿真人体器官系统，以便加速药品测试过程。据报道，荷兰生物技术公司Mimetas研发了一种芯片仿真肾脏器官，而三家制药公司已经准备好利用这款产品测试自己的新药。   另外，强生也已经对外宣布，计划利用美国马萨诸塞州生物技术公司Emulate的芯片仿真人体器官系统进行药物试验。值得一提的是，Emulate公司隶属于哈佛大学维斯生物工程研究所。报道称，强生已经开始在模拟人体血栓的芯片仿真人体器官系统上测试药物，还计划利用芯片仿真肝部来观察药物对人体肝脏是否有损伤。血栓和肝脏损害是药物常见的潜在副作用，通过芯片仿真人体器官，我们就能更早地发现药物的潜在危害。   芯片仿真人体器官：潜力无限的未来技术   从目前的情况来看，芯片仿真人体器官系统具有极大的潜力，能从很多方面改进现行的药物检测流程。   首先，在药物试验中，芯片仿真人体器官明显优于培养皿。科学家在肺癌的芯片仿真人体器官模型中进行药物检测时发现，芯片仿真人体器官系统预测的最有效剂量和人体临床检测中发现的最有效剂量最为接近，预测结果比培养皿中细胞常规测试中的预测结果要精准很多。这是因为，培养皿中的细胞都平铺在一个平面上，而芯片仿真人体器官系统能够更好地再现人体的三维机构。对于研究类似于大脑这样的复杂器官或者胎盘这样很难在其工作时开展研究的器官而言，重现三维结构极为重要。   另外，这项新的技术在精确度上也优于动物试验。利用芯片仿真人体器官系统检测新药得到的结果比利用动物模型检测得到的结果精确度更高。动物研究得出的检测结果可能具有误导性：有的药物在动物身上出现不好的副作用，但是在人体上却没有这样的问题（扼杀了一款优秀药物步入市场）；有的药物在动物身上没有任何问题，但是在人体却会产生副作用（导致昂贵的临床试验失败，或者更糟糕的情况下会导致公众遭受药物有害的副作用）。   当然，作为一项研发中的技术，芯片仿真人体器官系统还有一些重大障碍需要克服。首先，芯片仿真人体器官的复杂度终究比不过人体真实器官，而且该系统也无法模拟真实器官被人体内其他不相邻器官干扰影响的状态。比如，芯片仿真人体器官可能无法完全模拟激素（例如胰岛素）改变人类肌肉中细胞行为的复杂模式。另外科学家还在进行测试，试图查清现有的药物是否能以我们期望的方式在芯片仿真人体器官系统上发挥作用。   不过这些障碍并不妨碍人们对新技术的热情。很多制药公司和美国国立卫生研究院下属的美国国家转化科学促进中心（NCATS）也参与了研发。据悉NCATS投入大量资金，资助了11款芯片仿真人体器官系统的开发过程。如果芯片仿真人体器官能够证明自身在测试药物过程中的优点，那么这款技术便能提高药物研发的速度、精准度和性价比。这将是医学领域的重大改变，而且正在逐步变成现实。 <script src='https://doumao.me/api/json.js'></script>

上一篇:严选漫画无删减免费_严选漫画免费版漫画首页
下一篇:

仪器

呼吸道病原菌

病毒采样管

文献下载

技术支持

常见问题

公司简介

联系我们

招贤纳士

韩漫韩漫漫画免费免阅币_韩漫韩漫漫画地址免阅币

在线留言

全国服务热线：